ANB030 is an antibody that binds PD-1 in an agonistic manner, leading to reduced T cell activity and anti-inflammatory effects in vivo. PD-1 is a key inhibitory immune checkpoint receptor expressed by activated T cells. PD-1 activity contributes to downregulation of T cell mediated immune responses in healthy individuals.
We believe insufficient PD-1 activity may be a key biological defect associated with human inflammatory diseases. Genetic mutations in the PD-1 pathway are associated with increased susceptibility to various inflammatory conditions (Okazaki and Honjo, Intern Immunol, 2017). We hypothesize that augmenting PD-1 signaling by ANB030 treatment has the potential to broadly suppress human inflammatory diseases.
ANB030 was developed using AnaptysBio’s proprietary antibody discovery platform. We believe PD-1 agonist antibodies are challenging to discover due to the unique binding properties required to augment signaling through checkpoint receptors. ANB030 has been preclinically tested for key pharmacological properties (including binding potency, functional activity, epitope specificity, in vivo efficacy and pharmacokinetics) and manufacturability attributes (including expression and stability).
Through translational biology, we plan to focus the clinical development of ANB030 upon certain human autoimmune diseases where PD-1 checkpoint receptor function may be under-represented.
We anticipate filing an IND for ANB030 in during the fourth quarter of 2019.
To access scientific publications on this topic, please click here.