AnaptysBio Announces Fourth Quarter and Full Year 2020 Financial Results and Provides Pipeline Updates
- Positive topline data from GALLOP Phase 2 clinical trial of imsidolimab in moderate to severe generalized pustular psoriasis (GPP) announced in
October 2020 , with Phase 3 trial initiation anticipated in mid-2021 - Topline data from POPLAR Phase 2 imsidolimab clinical trial in palmoplantar pustulosis (PPP) anticipated in Q1 2021
- Expansion of imsidolimab program into four additional dermatological inflammatory Phase 2 clinical trials, including EGFRi-mediated skin toxicities, ichthyosis, hidradenitis suppurativa and acne, with top-line data readouts from Phase 2 trials anticipated through 2021 and 2022
- Advancement of ANB030 into a healthy volunteer Phase 1 trial with top-line data anticipated in mid-2021 and initiation of Phase 2 clinical trials in alopecia areata and vitiligo in Q4 2021
- Amended strategic immuno-oncology collaboration with GlaxoSmithKline (GSK) to increase dostarlimab royalties to 8-25% of global sales, add 1% Zejula™ royalty effective
January 2021 and receive additional$60 million cash in Q4 2020 - $75MM in cash milestones anticipated from dostarlimab regulatory milestones under GSK collaboration over upcoming 18 months, including US BLA and
EU MAA approval for dMMR endometrial cancer anticipated in H1 2021 and acceptance of US BLA for pan-dMMR tumors in Q1 2021
“We made progress in advancing AnaptysBio’s pipeline during 2020 and look forward to multiple clinical readouts from our wholly-owned programs in 2021. Imsidolimab will continue to be our key focus going forward as we anticipate GPP Phase 3 initiation and Phase 2 topline readouts from five other immune-dermatology indications through 2021 and 2022. We also anticipate commercial launch of dostarlimab this year and meaningful milestone and royalty revenue to
Imsidolimab (Anti-IL-36 Receptor) Program
- In July, we announced that the
U.S. Food and Drug Administration (FDA) has granted orphan drug designation for imsidolimab, our proprietary anti-interleukin-36 receptor (IL-36R) antibody, for the treatment of patients with GPP. - In October, we announced positive topline data from an interim analysis of our imsidolimab GALLOP Phase 2 trial in GPP. Six of 8 patients achieved the primary endpoint of disease improvement upon Day 29, while erythema with skin pustules, which clinically defines GPP, decreased by 94% on Day 29 relative to baseline. We plan to report 16-week data from the GALLOP trial at a medical conference in 2021.
- We anticipate initiation of a Phase 3 trial for imsidolimab in GPP during mid-2021 following completion of protocol alignment, and review of 16-week data from the Phase 2 GALLOP trial, with the FDA.
- We are also conducting a randomized, placebo-controlled, multi-dose Phase 2 trial in 59 patients with palmoplantar pustulosis, or PPP, also known as the POPLAR trial, with topline data anticipated in Q1 2021.
- We have expanded our imsidolimab program into third and fourth new clinical indications, EGFRi-mediated skin toxicities and ichthyosis, with interim top-line data from Phase 2 trials anticipated at the end of 2021 and in 2022, respectively, and we are also expanding the imsidolimab program into fifth and sixth new clinical indications, hidradenitis suppurativa and acne, with initiation of Phase 2 trials in these indications anticipated in Q2 2021.
- We initiated a worldwide registry of GPP and PPP patients, named RADIANCE, in Q1 2021, to improve understanding of the patient journey and support enrollment of future trials.
ANB030 (Anti-PD-1 Agonist) Program
- We anticipate topline data from our ongoing Phase 1 healthy volunteer clinical trial of ANB030, our wholly-owned PD-1 agonist antibody, designed to assess the safety, pharmacokinetics and pharmacodynamics of ANB030 in single and multiple ascending dose cohorts in mid-2021.
- Preclinical translational data using ANB030 was presented in
March 2020 at the Festival of Biologics Meeting. - We anticipate initiating Phase 2 trials of ANB030 in alopecia areata and vitiligo in Q4 2021.
ANB032 (Anti-BTLA Modulator) Program
- We filed a Clinical Trial Notification (“CTN”) in
Australia for ANB032, our wholly-owned BTLA modulator antibody, during the first quarter of 2021 and anticipate initiating a healthy volunteer Phase 1 trial in the first half of 2021 upon clearance of the CTN. - We presented preclinical data regarding ANB032 at the 2020
Federation of Clinical Immunology Societies (FOCIS) Virtual Annual Meeting inOctober 2020 .
Etokimab (ANB020 Anti-IL-33) Program
- We discontinued further development of etokimab, our anti-IL-33 antibody previously referred to as ANB020, following review of topline week 16 data from the approximately 100-patient ECLIPSE trial in chronic rhinosinusitis with nasal polyps (CRSwNP), where patients dosed with etokimab every four (q4w) or eight weeks (q8w) failed to achieve statistically significant over placebo on either co-primary endpoint.
Dostarlimab (Anti-PD-1 Antagonist) Program Partnered with GSK
- In
October 2020 , we amended our immuno-oncology collaboration with GSK resulting in increased financial consideration toAnaptysBio . Royalties due toAnaptysBio for dostarlimab were increased to 8-25% of global net sales, whereAnaptysBio will receive 8% of annual global net sales below$1 billion , and 12-25% of net sales above$1 billion . The$1.1 billion in cash milestone payments due under the collaboration agreement remain unchanged, andAnaptysBio anticipates receiving$75 million in such cash milestones over the next 18 months as dostarlimab obtains FDA and EMA regulatory approval for the first two indications. An additional$165 million in sales milestones is anticipated byAnaptysBio upon achievement of certain dostarlimab annual sales revenues. GSK also agreed, startingJanuary 1, 2021 , to payAnaptysBio a 1% royalty on all of GSK’s global net sales of Zejula. In addition, GSK paidAnaptysBio a one-time cash payment of$60 million in Q4 2020. In exchange,AnaptysBio provided GSK with freedom to conduct development and commercialization of Zejula in combination with third-party molecules and settled the dispute betweenAnaptysBio and GSK. - US BLA and European Union EMA approvals for dostarlimab are anticipated for endometrial cancer in H1 2021, which will result in
$20 million and$10 million milestone payments, respectively. The FDA recently accepted a subsequent US BLA for dostarlimab in pan-deficient mismatch repair tumors and we anticipate receiving a$10 million payment from GSK in Q1 2021 as a result of this milestone.
Board of Directors
- In
January 2021 , the Company appointed Dr.Magda Marquet to its board of directors. She is the co-founder ofAltheaDx , a commercial stage, precision medicine company, and co-founded Althea Technologies and as its co-CEO led the company to become a highly profitable, commercial company. Prior to starting Althea Technologies,Dr. Marquet held several positions in pharmaceutical development in companies such as Vical andAmylin Pharmaceuticals . She currently serves on the Board of Directors of Arcturus Therapeutics, Micronoma, Matrisys Biosciences and ProciseDx.
Fourth Quarter Financial Results
- Cash, cash equivalents and investments totaled
$411.2 million as ofDecember 31, 2020 compared to$428.5 million as ofDecember 31, 2019 , for a net decrease of$17.3 million . The decrease relates primarily to cash used for operating activities partially offset by an increase in collaboration revenue of$67.0 million . - Collaboration revenue was
$60.0 million and$75.0 million for the three and twelve months endedDecember 31, 2020 , which related to milestone payments for successful BLA and MAA filings for dostarlimab and the$60.0 million amendment related payment from GSK, compared to$3.0 million and$8.0 million for the three and twelve months endedDecember 31, 2019 . - Research and development expenses were
$21.6 million and$80.0 million for the three and twelve months endedDecember 31, 2020 , compared to$21.4 million and$99.3 million for the three and twelve months endedDecember 31, 2019 . The annual decrease was due primarily to reduced outside services for manufacturing and clinical activities based on the timing of projects. - General and administrative expenses were
$5.1 million and$18.9 million for the three and twelve months endedDecember 31, 2020 , compared to$3.8 million and$16.1 million for the three and twelve months endedDecember 31, 2019 . The increase was due primarily to increased legal and insurance expenses. - Net income was
$33.6 million for the three months endedDecember 31, 2020 , or a net income per share of$1.23 and a net loss of$19.9 million for the twelve months endedDecember 31, 2020 , or a net loss per share of$0.73 , compared to a net loss of$20.3 million and$97.3 million for the three and twelve months endedDecember 31, 2019 , or a net loss per share of$0.75 and$3.60 .
Financial Guidance
About
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to: the timing of the release of data from our clinical trials, including imsidolimab’s Phase 2 clinical trial in PPP, imsidolimab’s Phase 2 clinical trials in EGFRi, ichthyosis, hidradenitis suppurativa, and acne, and ANB030’s Phase 1 healthy volunteer clinical trial; the timing of initiation of imsidolimab’s Phase 2 clinical trials in hidradenitis suppurativa and acne; the timing of initiation of imsidolimab’s Phase 3 clinical trial in GPP; the timing of initiation of ANB032’s Phase 1 healthy volunteer clinical trial; the milestones and royalty payments to be received under the GSK collaboration; and our projected 2021 cash burn and cash runway. Statements including words such as “plan,” “continue,” “expect,” or “ongoing” and statements in the future tense are forward-looking statements. These forward-looking statements involve risks and uncertainties, as well as assumptions, which, if they do not fully materialize or prove incorrect, could cause our results to differ materially from those expressed or implied by such forward-looking statements. Forward-looking statements are subject to risks and uncertainties that may cause the company’s actual activities or results to differ significantly from those expressed in any forward-looking statement, including risks and uncertainties related to the company’s ability to advance its product candidates, obtain regulatory approval of and ultimately commercialize its product candidates, the timing and results of preclinical and clinical trials, the company’s ability to fund development activities and achieve development goals, the company’s ability to protect intellectual property and other risks and uncertainties described under the heading “Risk Factors” in documents the company files from time to time with the
Contact:
858.732.0201
dmulroy@anaptysbio.com
Consolidated Balance Sheets
(in thousands, except par value)
ASSETS | |||||||||
Current assets: | |||||||||
Cash and cash equivalents | $ | 250,456 | $ | 171,017 | |||||
Short-term investments | 143,197 | 203,210 | |||||||
Prepaid expenses and other current assets | 2,908 | 3,506 | |||||||
Total current assets | 396,561 | 377,733 | |||||||
Property and equipment, net | 1,783 | 1,618 | |||||||
Long-term investments | 17,546 | 54,305 | |||||||
Other long-term assets | 602 | 1,481 | |||||||
Restricted cash | 60 | 60 | |||||||
Total assets | $ | 416,552 | $ | 435,197 | |||||
LIABILITIES AND STOCKHOLDERS’ EQUITY | |||||||||
Current liabilities: | |||||||||
Accounts payable | $ | 4,217 | $ | 16,237 | |||||
Accrued expenses | 15,262 | 11,052 | |||||||
Notes payable, current portion | — | 1,375 | |||||||
Other current liabilities | 342 | 871 | |||||||
Total current liabilities | 19,821 | 29,535 | |||||||
Other long-term liabilities | — | 654 | |||||||
Stockholders’ equity: | |||||||||
Preferred stock, |
— | — | |||||||
Common stock, |
27 | 27 | |||||||
Additional paid in capital | 660,665 | 648,669 | |||||||
Accumulated other comprehensive (loss) income | (4 | ) | 338 | ||||||
Accumulated deficit | (263,957 | ) | (244,026 | ) | |||||
Total stockholders’ equity | 396,731 | 405,008 | |||||||
Total liabilities and stockholders’ equity | $ 416,552 | $ 435,197 |
Consolidated Statements of Operations and Comprehensive Income (Loss)
(in thousands, except per share data)
Three Months Ended |
Year Ended |
||||||||||||||||||
2020 | 2019 | 2020 | 2019 | ||||||||||||||||
Collaboration revenue | $ | 60,000 | $ | 3,000 | $ | 75,000 | $ | 8,000 | |||||||||||
Operating expenses: | |||||||||||||||||||
Research and development | 21,567 | 21,426 | 80,025 | 99,338 | |||||||||||||||
General and administrative | 5,088 | 3,832 | 18,854 | 16,094 | |||||||||||||||
Total operating expenses | 26,655 | 25,258 | 98,879 | 115,432 | |||||||||||||||
Income (loss) from operations | 33,345 | (22,258 | ) | (23,879 | ) | (107,432 | ) | ||||||||||||
Other income (expense), net: | |||||||||||||||||||
Interest expense | — | (200 | ) | — | (1,041 | ) | |||||||||||||
Interest income | 376 | 2,282 | 3,959 | 10,984 | |||||||||||||||
Other (expense) income, net | (75 | ) | (109 | ) | (11 | ) | 1 | ||||||||||||
Total other income (expense), net | 301 | 1,973 | 3,948 | 9,944 | |||||||||||||||
Income (loss) before income taxes | 33,646 | (20,285 | ) | (19,931 | ) | (97,488 | ) | ||||||||||||
Provision for income taxes | — | 22 | — | 152 | |||||||||||||||
Net income (loss) | 33,646 | (20,263 | ) | (19,931 | ) | (97,336 | ) | ||||||||||||
Other comprehensive (loss) income: | |||||||||||||||||||
Unrealized (loss) income on available for sale securities, net of tax of |
(263 | ) | (142 | ) | (342 | ) | 561 | ||||||||||||
Comprehensive income (loss) | $ | 33,383 | $ | (20,405 | ) | $ | (20,273 | ) | $ | (96,775 | ) | ||||||||
Net income (loss) per common share: | |||||||||||||||||||
Basic | $ | 1.23 | $ | (0.75 | ) | $ | (0.73 | ) | $ | (3.60 | ) | ||||||||
Diluted | $ | 1.20 | $ | (0.75 | ) | $ | (0.73 | ) | $ | (3.60 | ) | ||||||||
Weighted-average number of shares outstanding: | |||||||||||||||||||
Basic | 27,349 | 27,154 | 27,302 | 27,059 | |||||||||||||||
Diluted | 27,938 | 27,154 | 27,302 | 27,059 |
Source: AnaptysBio, Inc.