Advantages of immune cell modulation in the treatment of autoimmune and inflammatory diseases

Immune cell modulators (ICM) are a novel therapeutic class with the potential to treat autoimmune and inflammatory diseases across a broad range of therapeutic areas, including rheumatology, gastroenterology, respiratory, dermatology and neurology.

Anaptys’ ICMs are engineered to have a top-down, broad impact on the most pathogenic cells driving disease by targeting specific activated immune cells in periphery and tissue.

See our pipeline of investigation ICMs here

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Anaptys Publications and Relevant Literature

Rosnilimab

  • Poster Presentation
June, 2025 — Federation of Clinical Immunology Societies (FOCiS) Annual Meeting

Synovial Expression Levels of PD-1, the Target of Rosnilimab, Correlate with Disease Activity and Persist Across Disease Stages and Lines of Therapy in Rheumatoid Arthritis

Ren et al., 2025

  • Oral Presentation
June, 2024 — Federation of Clinical Immunology Societies (FOCiS) Annual Meeting

Rosnilimab, a PD-1 Agonist Antibody that Binds to a Membrane Proximal Epitope Leading to Optimized PD-1 Agonistic Signaling

Parmley et al., 2024

  • Poster Presentation
June, 2024 — Federation of Clinical Immunology Societies (FOCiS) Annual Meeting

Rosnilimab, a PD-1 Agonist Antibody that Binds to a Membrane Proximal Epitope Leading to Optimized PD-1 Agonistic Signaling

Parmley et al., 2024

  • Oral Presentation
May, 2024 — Digestive Disease Week (DDW) Annual Meeting

Optimizing PD-1 Agonist Signaling With Membrane Proximal Binding of Rosnilimab, a Clinical Stage PD-1 Agonist IgG1 Antibody

Parmley et al., 2024

  • Poster Presentation
February, 2024 — European Crohn’s and Colitis Organisation (ECCO) Congress

Optimizing PD-1 Agonist Signaling with Membrane Proximal Binding of Rosnilimab, a Clinical Stage PD-1 Agonist IgG1 Antibody

Parmley et al., 2024

Imsidolimab

  • Oral Presentation
October, 2021 — European Academy of Dermatology & Venereology (EADV) Annual Congress

Imsidolimab, an Anti-IL-36 Receptor Monoclonal Antibody, in the Treatment of Generalized Pustular Psoriasis: Results from a Phase 2 Trial

Gudjonsson et al., 2021

  • Poster Presentation
May, 2018 — European Academy of Allergy and Clinical Immunology (EAACI) Congress

A Phase 1 Study of ANB019, an Anti-Interleukin-36-Receptor (IL-36R) Monoclonal Antibody, in Healthy Volunteers

Khanskaya et al., 2018

  • Journal Publication
November, 2013 — Journal of Investigative Dermatology

The Majority of Generalized Pustular Psoriasis Without Psoriasis Vulgaris Is Caused by Deficiency of Interleukin-36 Receptor Antagonist

Sugiura et al., 2013

  • Journal Publication
August, 2012 — Current Opinion in Pharmacology

IL-36 in Psoriasis

Towne et al., 2012

  • Journal Publication
2012 — Expert Review of Dermatology

IL-36: a Potential Psoriasis Target?

Raison et al., 2012

  • Journal Publication
September, 2011 — The American Journal of Human Genetics

Mutations in IL36RN/IL1F5 Are Associated with the Severe Episodic Inflammatory Skin Disease Known as Generalized Pustular Psoriasis

Onoufriadis et al., 2011

  • Journal Publication
August, 2011 — The New England Journal of Medicine

Interleukin-36–Receptor Antagonist Deficiency and Generalized Pustular Psoriasis

Marrakchi et al., 2011

  • Journal Publication
October, 2007 — Journal of Experimental Medicine

Opposing Activities of Two Novel Members of the IL-1 Ligand Family Regulate Skin Inflammation

Blumberg et al., 2007

Immuno-Oncology

  • Poster Presentation
2016 — EORTC-NCI-American Association for Cancer Research Symposium on Molecular Targets and Cancer Therapeutics

Identification and Characterization of TSR-042, a Novel Anti-PD-1 Therapeutic Antibody

Laken et al., 2016

  • Poster Presentation
2016 — EORTC-NCI-American Association for Cancer Research Symposium on Molecular Targets and Cancer Therapeutics

Discovery of TSR-022, a Novel, Potent Anti-TIM-3 Therapeutic Antibody

Laken et al., 2016

  • Poster Presentation
2015 — American Association for Cancer Research Annual Meeting

Targeting PD-1, TIM-3 and LAG-3 in Combination for Improved Immunotherapy Combinations

Kehry et al., 2015

  • Poster Presentation
2015 — Keystone Symposium on Antibodies as Drugs

Generation of Anti-LAG-3 Monoclonal Antibodies for use in Immunotherapy Combinations

Jun et al., 2015

  • Poster Presentation
2014 — American Association for Cancer Research Special Conference on Tumor Immunology and Immunotherapy

Identification and Characterization of a Potent Anti-Human Tim-3 Antagonist

Correia et al., 2014

  • Poster Presentation
2014 — American Association for Cancer Research Annual Meeting

Generation of Antagonistic Anti-TIM-3 and LAG-3 Monoclonal Antibodies for Potential Novel Immunotherapy Combinations

Jun et al., 2014